PG01 is a potent CFTR Cl-channel potentiator, effective against deltaF508 (Ka 0.3 µM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 µM, 0.45 µM and 1.94 µM, respectively.PG01 increases deltaF508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.
Molecular Weight:
439.55
Purity:
99.87%
CAS Number:
[853138-65-5]
Formula:
C28H29N3O2
Target:
CFTR
T16516
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