Pyrazofurin is a pyrimidine nucleoside analogue that potently inhibits cell proliferation and DNA synthesis by targeting UMP synthase, while also acting as a highly sensitive orotate-phosphoribosyltransferase inhibitor with IC50 values ranging from 0.06 to 0.37 µM in Hep-2, HNSCC-14B, and HNSCC-14C cell lines, supporting the use of Pyrazofurin as a mechanistic probe for nucleotide biosynthesis inhibition and antiproliferative research.
Molecular Weight:
259.22
Purity:
98.17%
CAS Number:
[30868-30-5]
Formula:
C9H13N3O6
Target:
Dehydrogenase|||Proton pump
T16690
T16690
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