Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.
Molecular Weight:
591.1
Purity:
99.79%
CAS Number:
[1639351-92-0]
Formula:
C28H39ClN6O6
Target:
ADC Linker
T18321
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