LG100268 is a potent, selective, and orally active retinoid X receptor (RXR) agonist that agonizes RXR-alpha, RXR-beta, and RXR-gamma at the nanomolar level, selectively exceeding the RAR by three orders of magnitude.LG100268 is capable of inducing transcriptional activation in adipocytes, affecting the RXRs and their chaperone receptor, Foxl2/Dmrt1, to induce flounder masculinization in juvenile flounder, inhibits keratin 17 expression in nigrostriatal epithelial cells, and increases PD-L1 expression in HER2 or triple-negative breast cancer.
Molecular Weight:
363.49
Purity:
99.83%
CAS Number:
[153559-76-3]
Formula:
C24H29NO2
Target:
Retinoid Receptor|||Autophagy|||PD-1/PD-L1
T19703
T19703
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