NHTD, a KRAS-PDEdelta inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEdelta, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).
Molecular Weight:
422.47
CAS Number:
[2540915-70-4]
Formula:
C24H26N2O5
Target:
PDE|||Ras
T200095
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