GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKalpha/beta in the NF-kappaB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFkappaB and PGE2.
Molecular Weight:
412.39
CAS Number:
[1588866-45-8]
Formula:
C22H20O8
Target:
NF-kappaB|||IkappaB/IKK
T200141
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