Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 µM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.
Molecular Weight:
450.52
CAS Number:
[2019163-02-9]
Formula:
C24H34O8
Target:
p38 MAPK|||Apoptosis|||JAK|||JNK|||ERK|||STAT
T200239
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