ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.
Molecular Weight:
578.95
CAS Number:
[1622212-25-2]
Formula:
C24H18ClF3N6O4S
Target:
Trk receptor
T200301
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