NLRP3-IN-46 (Compound 3k) activates the cholinergic anti-inflammatory pathway involved in neuro-immune modulation, thereby inhibiting the activation of the NLRP3 inflammasome. Furthermore, NLRP3-IN-46 suppresses the production of IL-1beta in THP-1 cells induced by Uric acid sodium, making it relevant for research in gouty arthritis.
Target:
NOD-like Receptor (NLR)
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