GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 µM.
Molecular Weight:
994.99
CAS Number:
[2991588-80-6]
Formula:
C48H53Cl2N13O5S
Target:
PROTACs|||Glutathione Peroxidase|||Ferroptosis
T200693
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