NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 µM and 0.38 µM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.
Molecular Weight:
521.56
CAS Number:
[1352286-61-3]
Formula:
C31H27N3O5
Target:
TSH Receptor
T200723
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