Cetzole (Compound 1) acts as an inducer of ferroptosis (iron-dependent cell death) through the accumulation of ROS, leading to cell death. The compound exhibits varying half-maximal cytotoxic concentrations (CC50) against several cell lines: 2.56 µM in NCI-H522, 10.31 µM in NCI-H522 GFP-SCL7A11 8, 2.71 µM in NCI-H522 RV-GFP, 3.07 µM in HT-1080, 14.9 µM in NARF2, and 6.28 µM in MDA-MB-231. This highlights Cetzoles potential for research in cancer therapeutics.
Molecular Weight:
205.28
CAS Number:
[3043764-86-6]
Formula:
C11H11NOS
Target:
Ferroptosis
T200746
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