Neuroprotective agent 5 (compound 28) acts as a brain-penetrating agent with anti-neuroinflammatory, antioxidant, and neuroprotective properties. It exhibits potent inhibition of nitric oxide (NO) with an EC50 of 0.49 µM and suppresses the release of pro-inflammatory mediators PGE2 and TNF-alpha. Additionally, it downregulates the expression of iNOS and COX-2 proteins, facilitating the polarization of BV-2 cells from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. Neuroprotective agent 5 also dose-dependently inhibits acetylcholinesterase (AChE) activity and the aggregation of Abeta42. This compound is useful for research into Alzheimers disease.
Target:
NO Synthase|||COX|||Beta Amyloid|||Cholinesterase (ChE)
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