PLpro-IN-8 (compound 1) serves as an inhibitor of the SARS-CoV papain-like protease (PLpro), exhibiting IC50 values of 5.9 µM for SARS-CoV-2 PLpro and 0.46 µM for SARS-CoV-1 PLpro. Additionally, it hinders the Wuhan SARS-CoV-2 strain WK-521 with an EC50 of 2.7 µM.
Molecular Weight:
390.43
Formula:
C23H22N2O4
Target:
SARS-CoV
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