SJ46421, a PROTAC protein degrader derived from (+)-JQ-1, targets KLHDC2. It efficiently forms a stable ternary complex with KLHDC2, exhibiting an IC50 of 7.8 nM. Furthermore, SJ46421 promotes the polyubiquitination of the BD2 domain of BRD2, BRD3, or BRD4.
Molecular Weight:
837.41
Formula:
C42H41ClN8O5S2
Target:
Epigenetic Reader Domain|||PROTACs
T200999
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