Metallo-beta-lactamase-IN-16 (compound 18), a sulfone-containing metallo-beta-lactamase inhibitor, exhibits antimicrobial activity. It effectively inhibits various metallo-beta-lactamases, including NDM-1 (New Delhi metallo-beta-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona Integron-encoded Metallo-beta-lactamase), and VIM-2. The IC50 values for these enzymes are 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM respectively.
Molecular Weight:
480.54
CAS Number:
[2058069-25-1]
Formula:
C16H16N8O4S3
Target:
Antibacterial|||Beta-lactamase
T201021
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