PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein, Black: linker, Blue: ligand for E3 ligase)
Molecular Weight:
818.88
Formula:
C41H46N12O7
Target:
PROTACs|||Kinesin|||Aurora Kinase
T201080
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