CYP3A4-IN-4 (compound delta,-3) constitutes a Ru(II)-Ir(III) complex that acts as a photoactive inhibitor of the primary human drug-metabolizing enzyme CYP3A4. This complex features a [Ru(tpy)(Me2bpy)] photocaging group and exhibits an IC50 of 2.2 µM for the inhibition of microsomal CYP3A4 under irradiation conditions (lambdairr=530 nm, tirr=15 min). The phototherapeutic index (PI) of CYP3A4-IN-4 is 5.4.
Molecular Weight:
1656.19
Formula:
C80H61Cl3IrN11ORuS2
Target:
Cytochromes P450
T201084
* VAT and and shipping costs not included. Errors and price changes excepted
