WS-11 is a non-covalent reversible inhibitor of BTK, with IC50 values of 3.9 nM for the wild-type and 2.2 nM for the C481S mutant BTK. In addition to strong hydrogen bonding, WS-11 also forms robust pi-pi interactions with PHE540, and p-pi interactions with LYS430 within the active pocket.
Molecular Weight:
511.51
CAS Number:
[2759280-09-4]
Formula:
C26H22FN9O2
Target:
BTK
T201126
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