HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of 200 µM for Hsp90alpha and 7.3 µM for Hsp90beta. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0/G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERalpha, CDK4, and Akt.
Molecular Weight:
450.36
Formula:
C21H25Cl2N5O2
Target:
HSP|||Apoptosis
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