BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 µM. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.
Molecular Weight:
430.48
CAS Number:
[452350-43-5]
Formula:
C23H18N4O3S
Target:
Bcl-2 Family
T201286
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