PROTAC HIF-1alpha degrader-1 (compound V2) is an effective proteolysis-targeting chimeric (PROTAC) degrader of hypoxia-inducible factor-1alpha (HIF-1alpha), with an IC50 value of 7.54 µM. This compound exhibits anti-proliferative activity, reduces HIF-1alpha protein expression, and induces apoptosis.
Molecular Weight:
913.22
Formula:
C51H72N6O7S
Target:
HIF/HIF Prolyl-Hydroxylase|||PROTACs|||Apoptosis
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