MGD-4 is an orally active, Cereblon (CRBN)-dependent degrader of IKAROS proteins that demonstrates dose-dependent degradation of IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM). The compound effectively inhibits the growth of multiple myeloma.
Molecular Weight:
288.3
CAS Number:
[2991817-99-1]
Formula:
C14H16N4O3
Target:
IKZF
T201701
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