PF-07265028 is a highly potent and selective small-molecule inhibitor of hematopoietic progenitor cell kinase 1 (HPK1/MAP4K1). By blocking HPK1-mediated signal transduction, PF-07265028 enhances T-cell receptor-associated signaling, thereby lifting immune suppression and promoting antitumor immune responses. PF-07265028 exhibits significant activity at the cellular level (e.g., inhibition of pSLP76, IC50 approximately 17 nM). PF-07265028 is suitable for use in cancer research.
Molecular Weight:
472.59
Purity:
99.45%
CAS Number:
[2736458-30-1]
Formula:
C26H32N8O
Target:
MAPK
T202343
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