Emavusertib Tosylate, CAS [[2376399-41-4]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T202760
Supplier Catalog Number:
T202760
Alternative Catalog Number:
TGM-T202760-10MG,TGM-T202760-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.
Molecular Weight:
663.7
CAS Number:
[2376399-41-4]
Formula:
C31H33N7O8S
Target:
NF-kappaB|||IRAK|||Apoptosis|||FLT|||MyD88
T202760
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