DHFR-IN-22, CAS [[2941327-87-1]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T203218
Supplier Catalog Number:
T203218
Alternative Catalog Number:
TGM-T203218-10MG,TGM-T203218-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor that falls under the category of 2,4-diaminopyrimidine compounds. It demonstrates significant inhibitory activity against isolated DHFR enzyme and major nontuberculous mycobacteria (NTM) species, specifically Mycobacterium avium and Mycobacterium abscessus. The compound has an IC50 of 1.1 nM and a MIC of 1.5 µg/mL for M. abscessus, and an IC50 of 6.3 nM and a MIC of 0.1 µg/mL for M. avium, while its IC50 for human DHFR is 2100 nM. DHFR-IN-22 may be promising for developing new strategies to combat NTM infections.
Molecular Weight:
414.5
CAS Number:
[2941327-87-1]
Formula:
C22H30N4O4
Target:
DHFR|||Antibiotic|||Antibacterial
T203218
* VAT and and shipping costs not included. Errors and price changes excepted
