PDE1-IN-9 (Compound 7a) is a selective inhibitor of phosphodiesterase 1 (PDE1), targeting PDE1C with an IC50 value of 11 nM. It effectively reduces the mRNA expression of IL-1beta, IL-6, TNF-alpha, and iNOS, while also inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Additionally, PDE1-IN-9 demonstrates good metabolic stability in rat liver microsomes.
Molecular Weight:
441.57
CAS Number:
[2982945-41-3]
Formula:
C28H31N3O2
Target:
NO Synthase|||PDE
T203227
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