MC3343, a DNMT inhibitor with IC50 values of 5.7 µM for DNMT1 and 1.7 µM for DNMT3a, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation by specifically re-expressing genes that regulate this physiological process, and is able to show synergistic effects in combination with adriamycin and cisplatin (CDDP).
Molecular Weight:
461.52
Purity:
99.73%
CAS Number:
[1535187-91-7]
Formula:
C27H23N7O
Target:
DNA Methyltransferase
T203345
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