SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 µM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.
Molecular Weight:
1248.2
Purity:
99.34%
CAS Number:
[2497585-50-7]
Formula:
C58H62F4N9O14PS
Target:
PROTACs|||STAT
T203395
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