SBI-810 is a functional selective beta-arrestin-biased allosteric modulator of the neurotensin receptor 1 (NTSR1). In the presence of the endogenous ligand neurotensin (NT), SBI-810 regulates NTSR1 signaling through a G protein-specific mechanism. It fully antagonizes NT-induced Gq activation and partially antagonizes NT-induced Gi1 activation, allowing NTSR1 to activate GoA and G12.
Molecular Weight:
446.59
CAS Number:
[1849603-79-7]
Formula:
C27H34N4O2
Target:
Neurotensin Receptor
T203513
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