SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 µM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.
Molecular Weight:
541.61
Formula:
C29H34F3N5O2
Target:
Ras|||Raf
* VAT and and shipping costs not included. Errors and price changes excepted
