PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 µM. PB01 holds promise for research in the diabetes field.
Molecular Weight:
355.391
CAS Number:
[368434-78-0]
Formula:
C18H21N5O3
Target:
Reactive Oxygen Species|||Proteasome
T204296
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