RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp, demonstrating substantial anti-coronavirus activity with an EC50 of 0.68 µM against HCoV-OC43. By reversibly acylating the Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12), it exerts prolonged antiviral effects and shows synergistic anti-coronavirus activity with Molnupiravir.
Molecular Weight:
343.374
CAS Number:
[1101848-34-3]
Formula:
C19H21NO5
Target:
SARS-CoV
T204421
* VAT and and shipping costs not included. Errors and price changes excepted