ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.
Molecular Weight:
232.106
CAS Number:
[15533-81-0]
Formula:
C10H11Cl2NO
Target:
TRP/TRPV Channel
T204534
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