FUT8-IN-1 (Compound 37) is an inhibitor of alpha-1,6-fucosyltransferase (FUT8), with a dissociation constant (KD) of 49 nM and an IC50 around 50 µM. In the presence of FUT8, FUT8-IN-1 forms a highly active naphthoquinone imine intermediate, thereby inhibiting FUT8s enzymatic activity.
Molecular Weight:
380.91
Formula:
C23H25ClN2O
Target:
Transferase
T204573
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