cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.
Molecular Weight:
421.277
CAS Number:
[2987886-49-5]
Formula:
C19H18Cl2N4O3
Target:
cGAS
T204612
* VAT and and shipping costs not included. Errors and price changes excepted
