HGC652 is a molecular glue targeting E3 ubiquitin ligase TRIM21 (KD=0.061 µM), promoting its formation of a ternary complex with NUP98 to induce degradation of NUP155 and nuclear pore complex proteins. HGC652 inhibits proliferation and induces cell death in multiple cancer cell lines.
Molecular Weight:
449.6
Purity:
99.95%
CAS Number:
[3055558-98-7]
Formula:
C23H28FNO3S2
Target:
E1/E2/E3 Enzyme|||Molecular Glues
T204670
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