HLB-0532259, CAS [[2566733-45-5]] Preis auf Anfrage

Product Overview

• Article Name: HLB-0532259, CAS [[2566733-45-5]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T204754
• Supplier Catalog Number: T204754
• Alternative Catalog Number: TGM-T204754-10MG,TGM-T204754-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein, Black: linker, Blue: ligand for E3 ligaseCereblon)

Product Properties

• Molecular Weight: 748.827
• CAS Number: [2566733-45-5]
• Formula: C40H44N8O7
• Target: PROTACs|||Aurora Kinase

Images

T204754