EP4 receptor antagonist 7, CAS [[3035217-40-1]] Preis auf Anfrage

Product Overview

• Article Name: EP4 receptor antagonist 7, CAS [[3035217-40-1]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T204782
• Supplier Catalog Number: T204782
• Alternative Catalog Number: TGM-T204782-10MG,TGM-T204782-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4, with an IC50 of 1.1 nM. This compound inhibits PGE2-induced beta-arrestin recruitment in HEK293 cells with an IC50 of 0.9 nM. In RAW 264.7 macrophages, it reduces the expression of PGE2-induced IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C motif) ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase 1 (Arg1) mRNA. In the CT26 mouse colon cancer model, EP4 receptor antagonist 7, combined with an anti-PD-1 antibody, inhibits tumor growth and enhances CD8+ T cell infiltration into the tumor.

Product Properties

• Molecular Weight: 453.413
• CAS Number: [3035217-40-1]
• Formula: C24H18F3N3O3
• Target: Interleukin|||Prostaglandin Receptor

Images

T204782