Avitinib (Abivertinib) maleate dihydrate is a third-generation, irreversible, orally active selective EGFR inhibitor with IC50 values of 0.18 nM for EGFRL858R and EGFRT790M, and 7.68 nM for wild-type EGFR. Additionally, Avitinib maleate dihydrate functions as a BTK inhibitor, promoting apoptosis in mantle cell lymphoma cells and inhibiting BTK phosphorylation, demonstrating anticancer properties.
Molecular Weight:
639.631
CAS Number:
[1822357-78-7]
Formula:
C30H34FN7O8
Target:
BTK|||EGFR|||Apoptosis
T204873
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