TopoisomeraseIIalpha-IN-10 (Compound 13r) is a topoisomerase IIalpha inhibitor that binds to the active site of DNA when complexed with topoisomerase IIalpha. This binding is stabilized through interactions with DNA base pairs and amino acid residues. By intercalating into DNA, TopoisomeraseIIalpha-IN-10 induces apoptosis and disrupts the mitochondrial membrane potential in HCT116 cells, effectively inhibiting their growth with an IC50 of 4.37 µM. It is applicable for cancer research studies.
