AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 µM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.
Molecular Weight:
705.332
Formula:
C36H41ClN6O3S2
Target:
Histone Methyltransferase
T204900
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