HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.
Molecular Weight:
706.65
Formula:
C35H43Cl2F2N5O4
Target:
Apoptosis|||5-HT Receptor
T204966
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