Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folate metabolic pathway. This compound also inhibits the promastigote and amastigote forms of Leishmania major, with IC50 values of 1.43 µM and 3.78 µM, respectively.
Molecular Weight:
514.87
Formula:
C26H15ClN4O6
Target:
DHFR|||Parasite
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