NNK is a nitrosated derivative of nicotine that activates the ERK1/2 and PKCalpha signaling pathways, induces Bcl2 phosphorylation at Ser70, and activates c-Myc at Thr58 and Ser62, thereby promoting the proliferation and survival of human lung cancer cells, and is commonly used to establish lung cancer mouse models.
Molecular Weight:
207.23
Purity:
98.89%
CAS Number:
[64091-91-4]
Formula:
C10H13N3O2
Target:
Lipoxygenase
T20533
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