Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 µM. It significantly promotes Nur77 expression and apoptosis, exhibiting excellent growth inhibitory effects on HepG2 and MCF-7 cells, with an IC50 of less than 5 µM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, leading to apoptosis. This compound is applicable in cancer research.
Molecular Weight:
477.99
Formula:
C26H28ClN5O2
Target:
Apoptosis|||IRE1|||NR4A|||PERK
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