AH078 (compound 37) is a selective PROTAC degrader targeting CK1delta and CK1epsilon with low selectivity for CK1alpha. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1delta/CK1epsilon ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.
Molecular Weight:
963.15
Formula:
C51H60F2N10O5S
Target:
Casein Kinase
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