CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-beta signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.
Molecular Weight:
304.36
Purity:
99.64%
CAS Number:
[1082942-70-8]
Formula:
C15H16N2O3S
Target:
Akt|||PTEN|||TGF-beta/Smad|||DNA/RNA Synthesis
T205607
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