10-SLF is a PROTAC FKBP12 degrader. It facilitates the formation of a ternary complex between FKBP12 and FBXW7-R465C, leading to the proteasomal degradation of FKBP12 in a FBXW7-R465C-dependent manner. 10-SLF selectively reduces FKBP12 levels in cells that express FBXW7-R465C.
Molecular Weight:
1120.16
CAS Number:
[2765058-89-5]
Formula:
C59H76Cl2N4O13
Target:
PROTACs|||FKBP
T205612
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