Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor with an IC50 of 0.55 µM and exhibits a Keap1 binding affinity (Kd of 0.50 µM). This compound activates Nrf2, reducing reactive oxygen species (ROS) and pro-inflammatory cytokines (IL-1beta, IL-6). Additionally, Keap1-Nrf2-IN-25 provides protective effects against DSS-induced colitis.
